Research

Summary

I am a dedicated oncology and immunology researcher with over five years of experience spanning pharmacology, toxicology, and tumor microenvironment studies. My work integrates advanced wet‑lab techniques with scientific communication and cross‑functional collaboration; skills essential for both scientific discovery and medical affairs engagement.

As a Post‑Doctoral Associate in Dr. Ronald Buckanovich’s lab at the Magee‑Womens Research Institute (UPMC), I investigate how the stromal protein TGFBI shapes immune responses and therapeutic sensitivity in ovarian cancer. I design and optimize preclinical models, profile immune cells using high‑parameter flow cytometry and molecular assays, and analyze clinical trial samples to generate insights that support biomarker discovery and translational strategy.

My Ph.D. research at West Virginia University explored how environmental exposures-ultrafine carbon black, ozone, nanoparticles, and microbial imbalance-drive inflammation, lung-gut axis disruption, and systemic immune dysregulation. These studies connected inhalation toxicology with pharmacology, revealing mechanisms that influence disease progression and therapeutic outcomes.

Across my training, I have worked with murine cancer models, patient‑derived xenografts, acute lung injury systems, and DNA damage response knockout models. My technical expertise includes multicolor flow cytometry, cell sorting, qRT‑PCR, western blotting, ELISA, immunofluorescence, and in‑vivo techniques such as bone marrow transplantation and multiple drug administration routes.

Beyond the bench, I am committed to clear scientific communication, mentoring trainees, collaborating with clinicians and scientists, and preparing manuscripts, presentations, and grant materials. My work has resulted in numerous peer‑reviewed publications and cross‑disciplinary partnerships that advance scientific understanding and support clinical and medical affairs objectives.

I am driven by the goal of connecting discovery to impact-whether through generating high‑quality data that informs therapeutic development or communicating scientific insights that support healthcare decision-making. As I continue my career, I aim to contribute meaningfully to oncology innovation, scientific engagement, and patient‑centered research.

Research Publications

Mazumder M.H.H., Gandhi J, Majumder N, Wang L, Cumming RI, Stradtman S, Velayutham M, Hathaway QA, Shannahan J, Hu G, Nurkiewicz TR, Tighe RM, Kelley EE, Hussain S. Lung-gut axis of microbiome alterations following co-exposure to ultrafine carbon black and ozone. Part Fibre Toxicol. 2023 Apr 21;20(1):15.
Majumder, N., Deepak, V., Hadique, S., Aesoph, D., Velayutham, M., Ye, Q., Mazumder, M.H., Lewis, S.E., Kodali, V., Roohollahi, A. and Guo, N.L., 2022. Redox imbalance in COVID-19 pathophysiology. Redox Biology, p.102465.
Kodali, V., Afshari, A., Meighan, T., McKinney, W., Mazumder, M.H.H., Majumder, N., Cumpston, J.L., Leonard, H.D., Cumpston, J.B., Friend, S. and Leonard, S.S., 2022. In vivo and in vitro toxicity of a stainless-steel aerosol generated during thermal spray coating. Archives of Toxicology, pp.1-17.
Majumder, N., Velayutham, M., Bitounis, D., Kodali, V.K., Mazumder, M.H.H., Amedro, J., Khramtsov, V.V., Erdely, A., Nurkiewicz, T., Demokritou, P. and Kelley, E.E., 2021. Oxidized carbon black nanoparticles induce endothelial damage through CXC chemokine receptor 3-mediated pathway. Redox Biology, 47, p.102161.
Wu, L, Li, X, Lin, Q, Chowdhury, F, Mazumder MH, Du, W. FANCD2 and HES1 suppress inflammation-induced PPAR gamma to prevent haematopoietic stem cell exhaustion. British Journal of Hematology. 2021; 192(3): 652-663.
Lin, Q., Wu, L., Ma, Z., Chowdhury, F.A., Mazumder, H.H. and Du, W., 2020. Persistent DNA damage–induced NLRP12 improves hematopoietic stem cell function. JCI insight, 5(10).
Wu, L., Lin, Q., Ma, Z., Chowdhury, F.A., Mazumder, M.H.H. and Du, W., 2020. Mesenchymal PGD 2 activates an ILC2-Treg axis to promote proliferation of normal and malignant HSPCs. Leukemia, pp.1-14.
Ma, Z., Xu, J., Wu, L., Wang, J., Lin, Q., Chowdhury, F.A., Mazumder, M.H.H., Hu, G., Li,X. and Du, W., 2020. Hes1 deficiency causes hematopoietic stem cell exhaustion. Stem Cells, 38(6), pp.756-768.
L. Wu, Q. Lin, Z. Ma, F.A. Chowdhury, M.H.H. Mazumder, Wei Du, (2019) “Mesenchymal COX2-Derived PGD2 Activates an ILC2-Treg Axis to Promote Proliferation of Normal and Malignant HSPCs” Blood, The Journal of the American Society of Hematology. 134: 1208
Habib, A.M., Islam, M.S., Sohel, M., Mazumder, M.H.H., Sikder, M.O.F. and Shahik, S.M., 2016. Mining the proteome of Fusobacterium nucleatum subsp. nucleatum ATCC 25586 for potential therapeutics discovery: an in silico approach. Genomics & Informatics, 14(4), p.255.
Hasan, M.A., Khan, M.A., Sharmin, T., Mazumder, M.H.H. and Chowdhury, A.S., 2016. Identification of putative drug targets in Vancomycin-resistant Staphylococcus aureus (VRSA) using computer aided protein data analysis. Gene, 575(1), pp.132-143.
Datta, A., Mazumder, M., Hasan, H., Chowdhury, A.S. and Hasan, M., 2015. Functional and structural consequences of damaging single nucleotide polymorphisms in human prostate cancer predisposition gene RNASEL. BioMed research international, 2015.
Hasan, M.A., Mazumder, M.H.H., Chowdhury, A.S., Datta, A. and Khan, M.A., 2015. Molecular-docking study of malaria drug target enzyme transketolase in Plasmodium falciparum 3D7 portends the novel approach to its treatment. Source code for biology and medicine, 10(1), p.7.
Hasan, M.A., Khan, M.A., Datta, A., Mazumder, M.H.H. and Hossain, M.U., 2015. A comprehensive immunoinformatics and target site study revealed the corner-stone toward Chikungunya virus treatment. Molecular immunology, 65(1), pp.189-204.
Hasan, A., Mazumder, H.H., Khan, A., Hossain, M.U. and Chowdhury, H.K., 2014. Molecular characterization of legionellosis drug target candidate enzyme phosphoglucosamine mutase from Legionella pneumophila (strain Paris): an in silico approach. Genomics & informatics, 12(4), p.268.

Posters & Conferences

Ultrafine particle and ozone co-exposure predisposes to greater microbiome dysbiosis after acute lung injury, M.H.H. Mazumder, N. Majumder, T. Nurkiewicz, J. Shannahan,S. Hussain, Society of Toxicology Annual Meeting, Nashville, TN, 2023
Role of Nod-like receptor X1 in ozone-induced lung inflammation, N. Majumder, M. H. Mazumder, S. Hussain. Society of Toxicology Annual Meeting, Nashville, TN, 2023
Distinctive synergistic effect of carbon black and ozone co-exposure on inflammation and microbial dysbiosis, M.H.H. Mazumder, N. Majumder, S. Xie, T. Nurkiewicz, J. Shannahan,S. Hussain, Society of Toxicology Annual Meeting, San Diego, CA, 2022
Biochemical Predictors for Covid-19 Disease Course and Mortality, S Hussain, N Majumder, V Deepak, M Velayutham, MH Mazumder, A Roohollahi, S Wen, V Khramtsov, E Kelley, S Hadique, C62. Expanding our insight into covid-19, American Thoracic Society, A4576- A4576, 2022
Ozone Inhalation During Sensitization Primes for a Greater Allergic Inflammation and Lung Function Decline, S Hussain, N Majumder, L Shelling, Z Xie, G William, MH Mazumder, TP066 Air Pollution And Exposure Science, American Thoracic Society, 2021
Mesenchymal COX2-derived PGD2 activates an immunosuppressive ILC2-Treg axis and promotes leukemic cell proliferation, L. Wu, Q. Lin, Z. Ma, F.A. Chowdhury, M.H.H. Mazumder, Wei Du, American Society of Hematology (ASH) meeting, December 2019
Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function in mouse and human models of DNA repair deficiency and aging, L. Wu, Q. Lin, Z. Ma, F.A. Chowdhury, M.H.H. Mazumder, Wei Du, 2019 WVU Cancer Institute Annual Meeting, November 2019

Training & Workshops

Biomedical experiential learning training on Flow cytometry and aseptic cell sorting, West Virginia University Flow and Single cell analysis core facility, July 2022.
Workshop on Applied Genetics and Genomics for Biomedical Researchers, ICDDRB-IDeSHI-CMBT, 26-30 November 2017
Training on Laboratory Biosafety and Biosecurity, ICDDRB, 22-23 October 2017
Training on Molecular Drug Development and Protein Data Simulation, Molecular Drug Development Laboratory, Bangladesh Chemical and Scientific Institute of Research, Chittagong, 25-27 August 2017
Training on Introduction to Python Programming and Biopython, Bangladesh Bioinformatics and Computational Biology Association, 15-16 January, 2017
Training course on Animal Cell Culture Techniques for Advanced Research, Centre for Advanced Research in Sciences (CARS), University of Dhaka, 19-23 June, 2016
Training on Bioinformatics Methods & Applications in Genomics, Proteomics & Drug Discovery, Bangladesh Society for Bioinformatics, 5-6 November, 2015
Training on Basic Laboratory Technique, National Institute of Biotechnology, February 9-13, 2014
Training on Basic Molecular Biology Techniques, Chittagong Veterinary and Animal Sciences University, September, 2013

Experiences

Laboratory Experiences: Multicolor flow cytometry (BD Fortessa II, Cytek Aurora), Single-cell sorting (BD Aria II), Mammalian cell culture, In-vivo whole body inhalation co-exposure (murine), Flexivent 2.0, Scireq whole body plethysmograph, Immunofluorescence and Bright-field microscopy, QIAcuity one digital PCR, ELISA, DNA-RNA-Protein extraction from environmental and clinical samples, Western blot, Quantitative real-time PCR, Mice breeding (recombinant and timed), Mice colony maintenance, IP, IV, Oral gavage, intranasal and oropharyngeal drug administration, Retro-orbital injection, Mice bone marrow transplantation.

Writing & Management Skills: Proficient in manuscript preparation, review, and correction, Trained multiple graduate and undergraduate students at WVU, Trained several trainees at ICDDRB, Proficient in lab management, leadership, and in-detail record keeping

In-Silico: Protein structure design, Drug-drug interaction network (String, Cytoscape)

Software Skills: Basic programming knowledge (R Studio), Microsoft Office 2021, GraphPad Prism 9, FCS Express 7, Adobe Photoshop

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